Product No.：

LTE004

Synonyms:

Opdivo, ONO-4538, BMS-936558, MDX1106

Target:

mCCR8

Description:

Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments.

C–C chemokine receptor 8 (CCR8) is a chemokine receptor, whose ligands are CCL1, CCL8, and CCL18.

Recent studies reported selective CCR8 expression on tumor-infiltrating Tregs. In some murine models, CCR8+ Tregs highly express Treg-related molecules that are associated with suppressive functions, and anti-CCR8 antibody treatment reduces tumor volume and enhances anti-tumor immunity. CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy.

Source:

CHO

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Bioactivity: