Advanced Protein Technologies and Drug Development
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Product No.:
Synonyms:
CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP,
JPD, PALS, PDON1, PLS, cathepsin C
Description:
Cathepsin
C catalyses excision of dipeptides from the N-terminus of protein and peptide
substrates, except if the amino group of the N-terminus is blocked, the site of cleavage is on either side of a proline residue, the
N-terminal residue is lysine or arginine, or the structure of the peptide
or protein prevents further digestion from the N-terminus.
Cathepsin C appears to be a central coordinator for activation of many serine proteases in immune/inflammatory cells.
Preferential cleavage:
P2 |
P1 |
↓ |
P1′ |
P2′ |
P3′ |
P4′ |
not Arg |
not Pro |
↓ |
not Pro |
Xaa |
Xaa |
Xaa |
not Lys |
not Pro |
↓ |
not Pro |
Xaa |
Xaa |
Xaa |
Xaa = any amino acid residue
↓ = cleavage site
Source:
CHO/HEK
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity:
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