Catalog Number：

LT0130

Synonyms:

IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18

Description:

IL-18 is a pleiotrophic cytokine containing some structural homology to the IL-1 family. IL-18 is produced by monocyte/macrophage cells and, like IL-12, plays an important role in cell-mediated immune responses. As a co-stimulant for Th1-like cells, IL-18 induces production of IFN-g, GM-CSF, and IL-2 and it stimulates IL-2R a-chain expression and Th1 cell proliferation. Additionally, IL-18 augments the cytotoxicity of natural killer (NK) cells and enhances allospecific CTL activity. IL-18 shows species-specificity, with human IL-18 showing minimal activity in the murine system.

Sequence:

YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNED

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

SDS-PAGE result	HPLC result
	Signaling pathway: Source：www.wikipathways.org